Lethality and synthetic lethality in the genome-wide metabolic network of Escherichia coli
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چکیده
منابع مشابه
Lethality and synthetic lethality in the genome-wide metabolic network of Escherichia coli.
Recent genomic analyses on the cellular metabolic network show that reaction flux across enzymes are diverse and exhibit power-law behavior in its distribution. While intuition might suggest that the reactions with larger fluxes are more likely to be lethal under the blockade of its catalysing gene products or gene knockouts, we find, by in silico flux analysis, that the lethality rarely has co...
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ژورنال
عنوان ژورنال: Journal of Theoretical Biology
سال: 2005
ISSN: 0022-5193
DOI: 10.1016/j.jtbi.2005.04.025